It is not yet known if there has been an causalities.
Emergency crews rushed to the scene in Piccadilly Gardens after reports that the vehicle smashed into the City Tower building, close to the Metrolink stop, at 1pm on Monday.
"Police alongside colleagues in the Northwest Ambulance Service and Greater Manchester Fire and Rescue have been in attendance. "We would ask members of the public to avoid the area where possible whilst officers establish the full circumstances. "
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