Research shows that healthy diets lower epigenetic age while added sugar accelerates aging in midlife Black and White women.
By Hugo Francisco de SouzaReviewed by Susha Cheriyedath, M.Sc.Jul 31 2024 In a recent study published in the journal JAMA Network Open, researchers conducted a cross-sectional study of midlife-aged Black and White women to evaluate the impacts of diets on their epigenetic age. Their study comprised 342 women whose 3-day dietary intakes were scored using the Alternate Health Eating Index , the Alternate Mediterranean Diet , and a novel Epigenetic Nutrient Index .
Background Epigenetic clocks are biochemical tests that measure an individual’s biological aging independent of chronological age. They are based on differential DNA methylation and have been shown to accurately predict an individual’s susceptibility to chronic, age-associated disease risk . About the study The present study aims to address current gaps in the literature by evaluating the epigenetic age associations between established dietary scores , a novel Epigenetic Nutrient Index ), and the GrimAge2 epigenetic clock marker.
“This study developed a novel nutrient index after the Mediterranean-style diet, but via a nutrient-based approach rather than a food-based one. Nutrient selection was done a priori based on antioxidant and/or anti-inflammatory capacities as well as roles in DNA maintenance and repair documented in the literature.”
Mean scores across dietary indices were AHEI-2010=55.4 , aMED 3.9 , and ENI=13.5 , indicating low to moderate diet quality. Mean sugar intake was 61.5g .
Aging Chronic Chronic Disease DNA DNA Methylation Inflammation Mediterranean Diet Mortality Nutrients Oxidative Stress Smoking Stress
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