Monitoring serum S100B levels may reduce exposure to cranial CT scans, thereby reducing their number, in children with mild head trauma when a clinical decision algorithm is followed.
Serum S100B level monitoring does not reduce cranial CT scan recommendations in children with mild head trauma; however, a post hoc analysis involving only centers that followed a clinical decision algorithm showed a significant reduction in CCT scan recommendations.
In a post hoc analysis of four centers that followed a clinical decision algorithm, a significant reduction in CCT scan recommendations was noted in the S100B biomonitoring group . Compared with the control group, the S100B biomonitoring group showed a significant reduction in hospitalizations for monitoring .
No differences were noted in the intracranial injuries on the first scan or persistent clinical signs in the follow-up telephone interview.Based on the results of the post hoc analysis, the authors wrote, "societies in pediatrics and emergency medicine could issue recommendations along these lines.
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