A study led by the UAB Institut de Neurociències and published in the journal Nature Communications demonstrates in animal models how daily administration of cannabidiol (CBD), a substance obtained from the cannabis plant, extends lifespan and improves symptoms associated with Leigh syndrome.
Universitat Autonoma de BarcelonaSep 6 2024 A study led by the UAB Institut de Neurociències and published in the journal Nature Communications demonstrates in animal models how daily administration of cannabidiol , a substance obtained from the cannabis plant, extends lifespan and improves symptoms associated with Leigh syndrome. This severe mitochondrial disease affecting children is characterized by a progressive decline in cognitive and motor functions and premature death.
Drs. Emma Puighermanal and Albert Quintana, researchers from the Laboratory of Mitochondrial Neuropathology of the Institut de Neurociències at the Universitat Autònoma de Barcelona , have spent years studying the disease. They seek to understand the processes causing dysfunction of mitochondria, organelles in charge of providing energy to cells, and to find therapies capable of reverting this.
The results revealed that CBD acts at many levels within the cell, including activating a protein inside the cell nucleus known as PPARγ. This protein regulates the expression of many genes involved in the immune response, oxidation and mitochondrial function, and has been seen to be altered by the disease. Moreover, CBD increases the expression of the metallothionein protein, which enhances its antioxidant response.
The benefits we observed, together with CBD's safe and well-tolerated profile, show it to be a truly promising treatment for patients with Leigh syndrome."
Leigh Syndrome Syndrome Antioxidant Cannabis Cell Children Fibroblast Mitochondrial Disease Protein Research
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Cannabidiol demonstrated to alleviate symptoms of Leigh syndromeA study led by the UAB Institut de Neurociències and published in the journal Nature Communications demonstrates in animal models how daily administration of cannabidiol (CBD), a substance obtained from the cannabis plant, extends lifespan and improves symptoms associated with Leigh syndrome.
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