Men with cardiovascular disease risk factors, including obesity, face brain health decline a decade earlier-;from their mid 50s to mid 70s-;than similarly affected women who are most susceptible from their mid 60s to mid 70s, suggest the findings of a long term study, published online in the Journal of Neurology Neurosurgery & Psychiatry.
BMJ GroupNov 26 2024 Men with cardiovascular disease risk factors, including obesity, face brain health decline a decade earlier-;from their mid 50s to mid 70s-;than similarly affected women who are most susceptible from their mid 60s to mid 70s, suggest the findings of a long term study, published online in the Journal of Neurology Neurosurgery & Psychiatry .
To explore this further, they drew on 34,425 participants of the UK Biobank all of whom had had both abdominal and brain scans. Their average age was 63, but ranged from 45 to 82. The strongest influence of cardiovascular risk and obesity on brain neurodegeneration occurred a decade earlier in men than in women and was sustained over two decades, the data revealed. The effects were also stronger in men than they were in women.
The most vulnerable regions of the brain were the temporal lobes, located in the cerebral cortex, the brain's outer surface. These regions are involved in aural, visual, and emotional information processing, and memory-;regions affected early on in the development of dementia.
Cardiovascular Disease Adipose Alzheimer's Disease Blood Blood Pressure Dementia Diabetes Gene Grey Matter Heart High Blood Pressure Medical Research Neurodegeneration Neurology Neurosurgery Obesity Psychiatry Research Smoking Type 2 Diabetes UK Biobank
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