The Brazil midfielder was in action for his country in World Cup qualifiers against Venezuela last Friday and then Uruguay five days later.
Casemiro will miss Manchester United’s trip to Sheffield United on Saturday after sustaining a “small issue” while playing for Brazil, the club have said.
In an update on players on United’s official website following a session at their training ground on Thursday, the club said: “Casemiro was absent, having remained in Brazil, on the club’s advice, to recover as swiftly as possible from a small issue picked up while playing for his country.
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