A genetic treatment targeting the causal NRAS c.181C|A mutation in congenital melanocytic naevus.
By Pooja Toshniwal PahariaReviewed by Lily Ramsey, LLMJun 19 2024 In a recent study published in The Journal of Investigative Dermatology , researchers developed a genetic treatment targeting the causal NRAS c.181C>A mutation in congenital melanocytic naevus using small interfering ribonucleic acid to suppress its expression and induce lesion clearance.
Targeting the NRAS c.181C>A, p. pathogenic variation might be an effective precision medicine strategy for identifying disease persistence pathways. The researchers conducted live apoptosis experiments and used two equations to evaluate siRNA candidates for in silico allelic discrimination. They performed a quantitative polymerase chain reaction , followed by Western blotting for analysis.
The researchers examined genes with comparable target sequences and conducted pathway analyses. They used caspase-3/7 activation to evaluate apoptosis in four naevus patients during live imaging over seven days. Packing targeted siRNA in self-assembling siNRASQ61K-RTNPs prevents siRNA deterioration, enabling the successful delivery of targeted siRNA into a humanized mouse model and allowing human skin explant administration.
Ribonucleic Acid Allele Apoptosis Cancer Cancer Prevention Cell Children Dermatology Genes Genetic Imaging In Vivo Kinase Medicine Mutation Precision Medicine Protein Ras Proteins Receptor RNA RNA Sequencing Sirna Skin Stress Thyroid
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