CBD and EPA cream: Dynamic duo for youthful skin SkinAging Dermatology AirPollution SunExposure CBD EPA Skincare YouthfulSkin Beauty cannabidiol eicosapentaenoicacid
By Dr. Priyom Bose, Ph.D.Jun 6 2023Reviewed by Benedette Cuffari, M.Sc. Several studies have indicated the cosmetic potential of eicosapentaenoic acid and cannabidiol . A recent Journal of Cosmetic Dermatology study developed and examined the anti-aging potential of a new cream formulation that contains CBD and EPA.
Aging is associated with physiological changes, such as the breakdown of elastin and collagen, local inflammation, and induction of matrix metalloproteinases . These changes cause clinical signs of aging, including peri-ocular wrinkling, pigmentation, skin inflammation, fine lines and wrinkles, and reduced skin elasticity and hydration.
EPA supplementation can reduce cyclooxygenase-2 activity and participate in the synthesis of prostaglandin-E2 , the latter of which acts as a proinflammatory mediator upon injury due to UV exposure. A standard photoaging model was used to assess UVB-induced damage. To this end, HaCaT keratinocytes cells were stimulated with UVB, following which IL-8 and PGE2 were estimated, as both IL-8 and PGE2 have a crucial role in UVB-induced inflammation.
The combination of CBD- and EPA-based topical formulation restored tissue viability, which was almost comparable to naïve or non-UV irradiated tissues. Treated tissues also exhibited reduced cytokine levels, significant enhancement in the extracellular matrix , and restoration of skin morphology to normal architecture.
The efficacy of the CBD and EPA cream on skin elasticity, firmness, and hydration was also assessed, all significantly improving following treatment. A time-dependent improvement in skin hydration, firmness, and elasticity was found, along with a reduction in red spots. Thus, the long-term application of this newly formulated gel significantly improves skin aging.
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