CAR-T cell therapy, which targets a specific protein on the surface of cancer cells, causes tumors to shrink or disappear in about half of patients with large B-cell lymphoma who haven't experienced improvement with chemotherapy treatments.
Stanford Medicine Jul 11 2024 CAR-T cell therapy, which targets a specific protein on the surface of cancer cells, causes tumors to shrink or disappear in about half of patients with large B-cell lymphoma who haven't experienced improvement with chemotherapy treatments.
In September 2022, the FDA designated CD22-targeting CAR-T therapy for large B-cell lymphoma a Breakthrough Therapy, a move that is meant to speed the development and review of particularly promising drugs that may provide a substantial improvement over existing therapies for serious conditions.
Several trials have experimented with engineering CAR-T cells that recognize both CD19 and CD22 -; exploring whether a double volley of attack might eliminate cancer cells before they learn how to evade the treatment. Of the 38 patients, 68% saw their cancers shrink, and 53% achieved a complete response, meaning their cancers were no longer detectable.
Lymphoma Acute Lymphoblastic Leukemia Cancer CAR T-Cell Chemotherapy Clinical Trial Food Gene Leukemia Medicine Molecule Preclinical Protein Research T-Cell Therapeutics
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