In people with already high high-density lipoprotein (HDL) cholesterol levels, additional increases in HDL levels may be associated with an increased risk of cardiovascular diseases, finds a study published in Cardiovascular Diabetology.
] The Institutional Review Board of the Seoul National University Hospital approved this study . Due to the database’s anonymization per stringent confidentiality guidelines, the need for informed consents was waived.The study population was derived after excluding participants without information for high-density lipoprotein cholesterol level.
Changes in HDL-C levels were calculated by subtracting HDL-C level in the health screening between 2011 and 2012 by HDL-C level in the health screening between 2009 and 2010. Both HDL-C levels at baseline and changes in HDL-C levels were stratified into quartiles using the ranking procedure. The incidence of CVD was calculated as the number of events per 1,000 people-years .
Table 2 Association of change in high-density lipoprotein cholesterol levels with incident cardiovascular diseaseWhen evaluated the associations of changes in HDL-C levels in a longer period of time by subtracting HDL-C levels between 2009 and 2010 from HDL-C levels between 2013 and 2014, the 4th quartile of the change in HDL-C levels revealed a higher risk of CVD compared to the 1st quartile .
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