Patients with intermediate-risk breast cancer had similar rates of 10-year overall survival whether or not they underwent chest wall irradiation (CWI) after mastectomy, according to results from the BIG 2-04 MRC SUPREMO clinical trial presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10-13, 2024.
American Association for Cancer Research Dec 12 2024 Patients with intermediate-risk breast cancer had similar rates of 10-year overall survival whether or not they underwent chest wall irradiation after mastectomy, according to results from the BIG 2-04 MRC SUPREMO clinical trial presented at the San Antonio Breast Cancer Symposium , held December 10-13, 2024.
To evaluate the impact of post-mastectomy CWI in patients with intermediate-risk breast cancer, Kunkler and colleagues conducted the BIG 2-04 MRC SUPREMO phase III clinical trial. The international trial enrolled patients from several countries with: There were no significant differences in overall survival between those who received CWI and those who did not, with 81.4% and 82.0% of patients in the CWI and no CWI arms, respectively, alive after a median follow-up of 9.6 years. Although CWI reduced the risk of chest wall recurrence by over half, the absolute rate of chest wall recurrence was reduced by less than 2%, which Kunkler explained was a clinically insignificant difference.
"This study demonstrates that CWI after a mastectomy has no influence on 10-year overall survival for patients with intermediate-risk breast cancer," said Kunkler. "The results are important considerations for shared decision-making conversations between patients and clinicians, as many patients eligible for post- mastectomy CWI may not require the treatment."
Cancer Mastectomy Clinical Trial Histology Lymph Nodes Medical Research Research
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