The link between severe headache disorders headaches and the body's circadian clock in pain timing and thresholds will be studied with a $2.4 million grant from the National Institute of Neurological Disorders and Stroke (NINDS) to UTHealth Houston researchers.
University of Texas Health Science Center at HoustonJun 21 2024 The link between severe headache disorders headaches and the body's circadian clock in pain timing and thresholds will be studied with a $2.4 million grant from the National Institute of Neurological Disorders and Stroke to UTHealth Houston researchers.
The study builds on earlier research by Burish and Yoo, funded by the Will Erwin Headache Research Foundation and published in 2023 in the journal Neurology, which revealed that both cluster headache and migraine are strongly linked to the internal clock that regulates body processes known as the circadian system. Burish and Yoo became interested in the topic of circadian clock regulation in headaches due to the clear circadian feature from cluster headache patients.
"Both migraine and cluster headache, but cluster headache in particular, have an unusually circadian pattern of attacks," Yoo said. "And several of the treatments for cluster headache and migraine, like steroids and melatonin, strongly influence the core molecular machinery of our body's internal clock. We thought that these links were interesting. With Dr.
Related Stories"The circadian aspect of cluster headache and migraine are fascinating – something seems to get activated at the same time every day," Burish said. "A goal of our research is to understand that activation, with the hopes of someday preventing these headaches from occurring.
Biochemistry Cluster Headache Headache Laboratory Medical School Migraine Neurosurgery Pain Stroke
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