An analysis of the biomolecule substudy of the EAST–AFNET 4 trial has revealed that biomolecule concentrations in the blood of patients with atrial fibrillation can be used to identify patients at high and low cardiovascular risk. The findings were published in Cardiovascular Research.
Circulating biomolecules identify patients with atrial fibrillation at high risk of cardiovascular eventsAn analysis of the biomolecule substudy of the EAST–AFNET 4 trial has revealed that biomolecule concentrations in the blood of patients with atrial fibrillation can be used to identify patients at high and low cardiovascular risk.Atrial Fibrillation is the most common arrhythmia in elderly people. AF often occurs in patients with cardiovascular comorbidities with shared disease mechanisms.
Paulus Kirchhof, principal investigator of EAST–AFNET 4 and author on the paper, explained,"We were fortunate that we precisely could quantify thirteen biomolecules related to different disease processes in the EAST–AFNET 4 The highest-risk patient cluster mainly showed cardiometabolic disturbances, with elevated concentrations of the biomolecules BMP10, IGFBP7, NT-proBNP, ANGPT2 and GDF15. Patients in the lowest-risk cluster showed low concentrations of these biomolecules.
"Our findings call for future research into the effects of biomolecules on cardiovascular function. These patient clusters open new treatment options in each: Circulating biomolecules identify patients with atrial fibrillation at high risk of cardiovascular events retrieved 15 April 2024 from https://medicalxpress.com/news/2024-04-circulating-biomolecules-patients-atrial-fibrillation.html
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