Blood levels of 'free range' DNA may signal early detection of dementia and frailty johnshopkins IOSPress_STM
Background:Altered cell homeostasis, seen in cognitive decline and frailty, leads to cell death and turnover, releasing circulating cell-free DNA . Objective:The goal of this study is to determine if serum genomic cell-free DNA is associated with physical and cognitive decline i
n older adults. Methods:We used serum from 631 community-dwelling individuals from the Religious Orders Study or Rush Memory and Aging Project who were without cognitive impairment at baseline. ccf-gDNA fragments in serum were quantified using digital PCR. An array of cognitive and physical traits, risk of dementia, global cognition, and frailty at or nearest the time of blood draw were regressed on ccf-DNA, with adjustment for age, sex, race, and education.
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