A linear increase in the risk for chronic kidney disease progression is observed even in albuminuria ranges | 30 mg/g.
"Our study highlights that those higher levels of albuminuria below 30 mg/g still confer substantially increased risks for CKD progression and subsequent kidney failure in persons with CKD," they wrote.
"These findings raise an important question of whether any categorizations of albuminuria should remain in clinical and research practice or whether this concept should be replaced by using albuminuria as a risk factor for adverse clinical outcomes on a continuous scale," the authors added. Importantly, 63.5% of patients in the study were already receiving antiproteinuric therapy in the form of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers at baseline, the authors noted.
Therefore, "our findings further underscore that there is residual risk even for persons with CKD receiving ACE inhibitors or ARB therapy who have higher levels of albuminuria in the normoalbuminuric range.". The first author is Ashish Verma, MB, BS, of the Boston University Chobanian & Avedisian School of Medicine in Boston, Massachusetts.Patients only had UACR levels measured at a single timepoint at baseline, and the study cannot account for day-to-day variability.
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