A study in Arthritis Research & Therapy finds that vitamin D deficiency is common in systemic lupus erythematosus and the geographical location of residence is the primary determinant of plasma vitamin D levels rather than the disease activity.
]. All these studies, including the current study, emphasise that vitamin D levels can normalise with oral supplementation and is safe. However, the effect on lupus activity and IFN signature are still not established. This could be because of the variable duration of several studies and the use of background immunosuppressive agents whose effect might be so high that added impact of vitamin D may not be evident.
The strength of our study is the large sample size with details about the usual confounders for vitamin D levels. Moreover, the samples were collected at the beginning of recruitment into the cohort, thus decreasing the effect of background immunosuppressive agents. The sample collection in both the centres was conducted round the year, which negates the effect of seasonal variation in vitamin D levels.
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