Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with an increased risk of cardiovascular (CV) disease in the general population.
Clonal hematopoiesis of indeterminate potential has been associated with an increased risk of cardiovascular disease in the general population. Currently, it is unclear whether this association is observed in large clinical trial cohorts with a high burden of existing CV disease or whether CV therapies can mitigate CHIP-associated CV risk.
Division of Cardiology, Institute for Human Genetics and Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USAPatrick T. EllinorN.A.M. developed the analysis plan, oversaw the analyses, interpreted the results and drafted the paper. J.P.P. led the CHIP calling and data preparation and contributed to the initial draft of the paper. G.E.M.M. led the statistical analyses and contributed to the initial and subsequent drafts of the paper. F.K.
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