A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has developed a comprehensive set of innovative genetic tools and mouse lines, called iFlpMosaics, designed to enhance the study of gene function and its implications in health and disease.
Centro Nacional de Investigaciones Cardiovasculares Carlos III Dec 14 2024 A team at the Centro Nacional de Investigaciones Cardiovasculares has developed a comprehensive set of innovative genetic tools and mouse lines, called iFlpMosaics, designed to enhance the study of gene function and its implications in health and disease.
The study highlights the iFlpMosaics toolkit's utility across different experimental setups, detailing how it allows scientists to track the effects of single or multiple gene deletions within the same tissue. This advance opens the way to deeper insight into the function of genes in cell biology, regeneration, and disease.
The iFlpMosaics toolkit is unburdened by these shortcomings and allows researchers to induce genetic mosaics with high throughput and precision, making it easier to study cell-autonomous gene function directly within the same organism. The toolkit not only enhances the understanding of genetic mutations in tissue development and disease processes, but also facilitates the study of complex interactions between cells within their microenvironment.
Genetic Cell Cellular Biology Genes Research
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