Colchicine does not significantly reduce perioperative atrial fibrillation (AF) or myocardial injury after non-cardiac surgery (MINS) in patients undergoing major non-cardiac thoracic surgery, according to late breaking research presented in a Hot Line session today at ESC Congress 2023.
Colchicine does not significantly reduce perioperative atrial fibrillation or myocardial injury after non-cardiac surgery in patients undergoing major non-cardiac thoracic surgery, according to late breaking research presented in aPerioperative AF occurs in approximately 10% of patients after major thoracic surgery, while MINS has an incidence of about 20% in the same patient population. Patients with perioperative AF and MINS have a poor prognosis.
Participants were randomly assigned in a 1:1 ratio to receive oral colchicine 0.5mg twice daily or matching placebo, starting within four hours before surgery and for a total duration of 10 days. Two co-primary outcomes were assessed during 14 days of follow up: 1) clinically important perioperative AF and 2) MINS .
In post-hoc analyses, the composite outcome of clinically important perioperative AF or MINS occurred in 360 patients in the colchicine group and in 415 patients in the placebo group . No treatment was required in 66 cases of diarrhea, 15 patients needed intravenous hydration, 2 received antibiotics, and 1 patient required readmission for diarrhea. In the colchicine group, the median length of stay was 5 days in patients with diarrhea and 5 days in those without diarrhea.
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