Colts vs. Jaguars predictions, odds, best bets for Week 5: Can Indy overcome Richardson, Taylor injuries?

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Colts vs. Jaguars predictions, odds, best bets for Week 5: Can Indy overcome Richardson, Taylor injuries?
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The NFL Week 5 odds favor the Jaguars to take down the Colts, and we provide predictions and best bets for the AFC South showdown.

Indianapolis Colts wide receiver Josh Downs celebrates a touchdown during an NFL football game against the Pittsburgh Steelers, Sunday, Sept. 29, 2024, in Indianapolis.The Jaguars are desperately searching for an elusive first win of the year, especially before a two-week road trip in London starting Week 6. Meanwhile, the Colts need a victory on Sunday afternoon to get above .500 and make ground on the AFC South-leading Texans.

Considering the vast differences in each QBs style of play, it must be difficult for the Jaguars to form a stable defensive game plan. Richardson is far more mobile than Flacco, while Joe Cool is a much better passer. However, the Jaguars are one of four teams with no interceptions forced, which bodes well no matter which QB starts the game.

Rookie WR Brian Thomas Jr. has been an excellent offseason addition, leading Jacksonville in targets, catches and receiving yards. The former LSU Tiger has yet to break 100 yards in a game, and Week 5 could be the first time he reaches triple digits.

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