A research team from Columbia Engineering and the Irving Institute for Cancer Dynamics has made a significant discovery in the field of cancer immunotherapy for relapsed acute myeloid leukemia (AML). The team identified a specific population of T cells that play a critical role in successful treatment response. The study, published in Science Immunology, suggests that the patient's immune environment, rather than the donor's, is the key factor determining treatment success. This finding could lead to new intervention strategies, such as enhancing the patient's immune environment before treatment.
Columbia University School of Engineering and Applied ScienceJan 24 2025 A research team from Columbia Engineering and the Irving Institute for Cancer Dynamics made a pivotal discovery in the field of cancer immunotherapy. In a paper published today in Science Immunology, the team identified a specific population of immune cells that play a critical role in successful treatment of relapsed acute myeloid leukemia . This work was in collaboration with the Dana Farber Cancer Institute .
Led by Elham Azizi, associate professor of biomedical engineering at Columbia Engineering, the research explores how coordinated immune networks in leukemia bone marrow microenvironments influence responses to cellular therapy, raising the question: why do some patients benefit from immunotherapy while others do not? The current treatment for relapsed AML, donor lymphocyte infusion -a therapy involving donor immune cells-has a 5-year survival rate of only 24%, according to research conducted by...
Utilizing the team's proprietary computational DIISCO approach, the researchers discovered key interactions between the unique T cell population and other immune cells may lead to patient remission. They also traced these T cells back to the donor product. However, it was discovered that the donor's immune cell composition has little to no effect on the patient's success. In fact, the success of this treatment is determined by the patient's immune environment.
Related Stories"This research exemplifies the power of combining computational and experimental methods through close collaboration to answer complex biological questions and uncover unexpected insights," said Azizi, who is a member of the Irving Institute for Cancer Dynamics, the Herbert Irving Comprehensive Cancer Center, and Columbia's Data Science Institute.
IMMUNOTHERAPY CANCER LEUKEMIA T CELLS PATIENT RESPONSE
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Researchers identify key factors for successful donor lymphocyte infusion in AML patientsDana-Farber Cancer Institute researchers have identified factors that determine whether donor lymphocyte infusion (DLI), a standard therapy for patients with acute myeloid leukemia (AML) who have relapsed after allogenic hematopoietic stem cell transplant, will successfully move the patient into remission.
Read more »
Can Britain Reclaim Its Lead in the Engineering Biology Revolution?This article explores the potential of engineering biology, a field that transforms waste materials into valuable products, and Britain's struggle to maintain its leading position.
Read more »
Gatwick Airport: Key rail routes to be affected by engineering workOn Sunday, buses will replace trains between East Croydon and Gatwick Airport.
Read more »
Glasgow Rail Passengers Face Disruption This Weekend Due to Industrial Action and Engineering WorksTrain services between Glasgow and London will be disrupted this weekend due to both industrial action and engineering works. Passengers are advised to check before they travel.
Read more »
Prompt Engineering Improves Code Output from LLMsA study by Anthropic demonstrates that Large Language Models (LLMs) can generate significantly better code when provided with clear and detailed prompts. While LLMs can produce functional code, incorporating prompt engineering techniques leads to substantial performance improvements.
Read more »
Prompt Engineering Boosts LLM Code GenerationLLMs can write better code with the right prompts, but novice programmers may struggle to leverage this effectively. An experiment using Anthropic's Claude LLM showed that iterative prompting and prompt engineering can significantly improve code performance.
Read more »