Researchers at the Francis Crick Institute, in collaboration with Revolution Medicines, have tested a combination of treatments in mice with lung cancer and shown that these allow immunotherapies to target non-responsive tumors.
The Francis Crick InstituteSep 25 2024
The researchers combined a newly identified KRAS G12C inhibitor, with a compound that blocks a protein called SHP2, which inhibits cancer cells and can also activate tumor immunity. The team believe that these targeted compounds provide a window of opportunity where the immune checkpoint inhibitor can kick into gear and allow the body's natural defenses to attack the tumor.
Immunotherapy Lung Cancer Cold Drugs Immune System Laboratory Oncogene Protein Research
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