A new study led by investigators from Mass General Brigham has identified a unique brain network that links varied patterns of brain atrophy, or shrinkage, associated with schizophrenia.
Brigham and Women's Hospital Dec 12 2024 By combining neuroimaging data from multiple studies involving more than 8,000 participants, the research team found a specific connectivity pattern of atrophy that was present across different stages and symptoms of schizophrenia -; and distinct from brain networks associated with other psychiatric disorders.
Ahmed T. Makhlouf, MD, corresponding author of the Center for Brain Circuit Therapeutics and medical director of the Brigham and Women's Hospital Psychosis Program "One explanation could be that everyone's actually looking at the same thing from a different vantage point. If multiple people try to feel different parts of an elephant with their eyes closed, they're going to describe different things," said senior author Shan H. Siddiqi, MD, a psychiatrist at the Brigham's Center for Brain Circuit Therapeutics. "Our approach with this study was to try to reconstruct the elephant.
Related StoriesFirst, the investigators constructed a common brain map combining the widespread locations of atrophy in schizophrenia. Then, they used a technique known as coordinate network mapping to estimate the overlap between atrophy locations and functional brain networks. The resulting atrophy connectivity map overlapped with schizophrenia-associated brain regions, including the bilateral insula, hippocampus and fusiform cortex.
Schizophrenia Brain Stimulation Clinical Trial Depression Hospital Medical School Mental Health Neuroanatomy Neuroimaging Psychosis Research Therapeutics
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