New research from investigators at Mass General Brigham suggests that a commonly used type 2 diabetes medication is linked to a higher rate of heart-related conditions compared to medications that hit other targets.
Mass General BrighamJul 24 2025 The study examined nationwide data from nearly 50,000 patients treated with different sulfonylureas and found that glipizide – the most widely used drug in the U.S. within this category – was linked to higher incidence of heart failure , related hospitalization and death compared to dipeptidyl peptidase-4 inhibitors. Results are published inJAMA Network Open.
Alexander Turchin, MD, MS, corresponding author of the Division of Endocrinology at Brigham and Women's Hospital
Type 2 Diabetes Cardiac Arrest Endocrinology Health Insurance Healthcare Heart Heart Failure Hospital Proteomics Research Stroke
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