Excessive scarring shown to be associated with atopiceczema, hypertension and musculoskeletal diseases kingscollegelon JAMADerm
This cross-sectional UK Biobank study of 972 people with excessive scarring and 229 106 controls identified associations of excessive scarring with atopic eczema and hypertension, with evidence that associations may vary with ethnicity. A phenome-wide scan of this predominantly White cohort identified a range of previously unreported correlations; musculoskeletal disease and pain symptoms were prominent nondermatological associations.
Of 502 701 UKB participants, analyses were restricted to 230078 individuals with linked primary care records.Previously studied disease associations and phenotypes defined in the PheWAS Catalog.Of the 972 people with excessive scarring, there was a higher proportion of female participants compared with the 229 106 controls and a lower proportion of White ethnicity ; mean age of the total cohort was 64 years.
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