Comparing clinical characteristics and outcomes of critically ill COVID-19 patients with a chohort admitted to ICU for influenza pneumonia APHP Cesp_Inserm COVID19 coronavirus covid infleunza pneumonia disease
By Tarun Sai LomteMay 19 2023Reviewed by Danielle Ellis, B.Sc. A recent study published in the Journal of Infection evaluated clinical differences between critically ill coronavirus disease 2019 and influenza patients.
Patients required appropriate International Classification of Diseases, Tenth Revision codes for the diagnosis of influenza or COVID-19 for inclusion. Age, sex, and simplified acute physiology score II were recorded at admission, and the Charlson comorbidity index was calculated. Patients with medullar aplasia, solid organ transplants, agranulocytosis, or cancer treatment were deemed immunocompromised.
Subsequently, a multivariable analysis was adjusted for a predefined set of confounders such as age, infection type, sex, heart disease, diabetes mellitus, cancer, immunosuppression, modified SAPS-II, hematologic malignancies, arterial hypertension, and chronic kidney disease. The association between infection type and in-hospital death was also determined.
COVID-19 was associated with a reduced likelihood of invasive ventilation and an increased in-hospital mortality risk without invasive ventilation. Prone positioning was used for 19% and 12% of COVID-19 and influenza patients, respectively, whereas ECMO was used for 1% of patients in each cohort. The COVID-19 cohort was less likely to require vasopressors and renal replacement therapy than the influenza cohort.
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