A study published in Diabetology & Metabolic Syndrome finds that in type 2 diabetes patients, random lipid profile correlates significantly with fasting lipid profile with little difference. Thus, it can be a reliable alternative for fasting lipid profile.
]. Moreover, our study suggests that the difference between the fasting and random lipid profiles did not differ significantly in different age and sex groups of patients. In addition, the finding was similar irrespective of diabetic drugs or lipid-lowering therapy. Although it was previously shown that lipid-lowering therapy does not affect the concordance between fasting and random lipid levels among patients with cardiovascular diseases [], the evidence was not exclusive to T2DM patients.
T2DM patients have an elevated risk of cardiovascular diseases, further augmented by dyslipidemia. Although the fasting lipid profile has long been used as a risk predictor of cardiovascular diseases, emerging evidence suggests that random blood samples for lipid measurement do not attenuate the value of cardiovascular risk prediction []. The present study’s findings support the potentiality of a random lipid profile as an alternative to a fasting lipid profile.
The present study has several limitations. First, we considered only TG, LDL-C, HDL-C, and TC for fasting and random lipid profiles; other parameters, including VLDL, chylomicrons, Apo-B, etc., were not measured. In addition, lipid measurements were not done in a single laboratory, which may influence the study results. Moreover, we included T2DM patients irrespective of their glycemic status and lipid levels, which could impact the correlation between fasting and random lipid levels.
Kim M, Suk J, Kim H, Jung H, Kim T, Park J. Post-prandial lipid levels for assessing target goal achievement in type 2 Diabetic Patients taking statin. J Korean Med Sci. 2010;25:387.
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