Consuming foods with erythritol increases risk of cardiovascular events, study shows

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Consuming foods with erythritol increases risk of cardiovascular events, study shows
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New Cleveland Clinic research shows that consuming foods with erythritol, a popular artificial sweetener, increases risk of cardiovascular events such as heart attack and stroke.

Cleveland ClinicAug 8 2024 New Cleveland Clinic research shows that consuming foods with erythritol, a popular artificial sweetener, increases risk of cardiovascular events such as heart attack and stroke. The findings, from a new intervention study in healthy volunteers, show erythritol made platelets more active, which can raise the risk of blood clots. Sugar did not have this effect.

Erythritol and other artificial sweeteners are common replacements for table sugar in low-calorie, low-carbohydrate and "keto" products. Erythritol is about 70% as sweet as sugar and is produced through fermenting corn. After ingestion, erythritol is poorly metabolized by the body. Instead, it goes into the bloodstream and leaves the body mainly through urine. The human body creates low amounts of erythritol naturally, so any additional consumption can accumulate.

The current research builds on the team's previous study, published last year in Nature Medicine, which revealed that cardiac patients with high erythritol levels were twice as likely to experience a major cardiac event in the following three years compared to those with low levels. The study also discovered that adding erythritol to patients' blood or platelets increased clot formation. These findings were confirmed by pre-clinical studies.

W. H. Wilson Tang, M.D., study co-author, research director for Heart Failure and Cardiac Transplantation Medicine at Cleveland Clinic "I feel that choosing sugar-sweetened treats occasionally and in small amounts would be preferable to consuming drinks and foods sweetened with these sugar alcohols, especially for people at elevated risk of thrombosis such as those with heart disease, diabetes or metabolic syndrome," Dr. Hazen advises. "Cardiovascular disease builds over time, and heart disease is the leading cause of death globally. We need to make sure the foods we eat aren't hidden contributors.

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