Patients with advanced EGFR-mutated NSCLC who were given osimertinib plus chemotherapy up front continue to show improved outcomes after initial progression, suggests ongoing trial data.
The results, presented on March 21 at the European Lung Cancer Congress 2024 , also suggest a potential overall survival benefit with the addition of chemotherapy to the third-generation EGFR-tyrosine kinase inhibitor.
The combination therapy was associated with a longer time to second-line treatment at a median of 30.7 months vs 25.4 months for osimertinib alone . Of the 46% of patients in the combination group who started second-line therapy, 37% received a non–platinum-based chemotherapy and 32% received a platinum-based chemotherapy; 14% began an EGFR tyrosine kinase inhibitor other than osimertinib.
Finally, the second interim overall survival analysis revealed an "encouraging trend" in favor of the combination, said Lama, after a median follow-up of approximately 31 months in both study arms and a data maturity of 41%. But, de Langen asked, is the benefit seen with this combination large enough to justify providing it as first-line treatment for all our patients? The chemotherapy is "an treatment with cytotoxic side effects, and patients have to go into the clinic every 3 weeks."
Although the results show a consistent benefit in favor of osimertinib plus chemotherapy, it comes "at the cost of additional toxicity," de Langen said.
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