The soap star, who is suing Mirror Group Newspapers, has given evidence at the High Court.
has said press intrusion into his private life left him feeling “extremely paranoid”.
“Whilst most people know the truth now, the defendant’s actions caused irreversible damage to a lot of my friendships at the time, as well as damage to my reputation,” he told the court.“I also became extremely paranoid about stories coming out and blamed innocent people close to me. “I treated them with immense suspicion, and eventually abandoned my local pub as I felt so paranoid. I now deeply regret this.”
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Polymyxin B therapy based on therapeutic drug monitoring in carbapenem-resistant organisms sepsis: the PMB-CROS randomized clinical trial - Critical CareBackground The appropriate administration regimen of polymyxin B is yet controversial. The present study aimed to explore the optimal dose of polymyxin B under therapeutic drug monitoring (TDM) guidance. Methods In China’s Henan province, 26 hospitals participated in a randomized controlled trial. We included patients with sepsis caused by carbapenem-resistant Gram-negative bacteria (CR-GNB) susceptible to polymyxin B. The patients were randomly divided into a high-dose (HD) group or a low-dose (LD) group and received 150 mg loading dose, 75 mg every 12 h and 100 mg loading dose, 50 mg every 12 h, respectively. TDM was employed to determine if the dose of polymyxin B needs adjustment based on the area under the concentration–time curve across 24 h at a steady state (ssAUC0–24) of 50–100 mg h/L. The primary outcome was the 14-day clinical response, and the secondary outcomes included 28- and 14-day mortality. Results This trial included 311 patients, with 152 assigned to the HD group and 159 assigned to the LD group. Intention-to-treat analysis showed that the 14-day clinical response was non-significant (p = 0.527): 95/152 (62.5%) in the HD group and 95/159 (59.7%) in the LD group. Kaplan–Meier’s 180-day survival curve showed survival advantage in the HD group than in the LD group (p = 0.037). More patients achieved the target ssAUC0–24 in the HD than in the LD group (63.8% vs. 38.9%; p = 0.005) and in the septic shock subgroup compared to all subjects (HD group: 71.4% vs. 63.8%, p = 0.037; LD group: 58.3% vs. 38.9%, p = 0.0005). Also, the target AUC compliance was not correlated with clinical outcomes but with acute kidney injury (AKI) (p = 0.019). Adverse events did not differ between the HD and LD groups. Conclusion A fixed polymyxin B loading dose of 150 mg and a maintenance dose of 75 mg every 12 h was safe for patients with sepsis caused by CR-GNB and improves long-term survival. The increased AUC was associated with increased incidence of AKI, and TDM results
Read more »
Piers Morgan knew how to hack phones and explained how, former Mirror journalist tells High CourtWhile Coronation Street star Michael Turner, who plays Kevin Webster, spent the most time in the witness box on Monday, the court also heard from the Mirror's former group political editor, who gave evidence about his time working for the newspaper's former editor Piers Morgan.
Read more »
Black Mirror: why show made major change to season 6Why did Black Mirror’s creator go back to the past?
Read more »
Canada’s Alpha Auto Group revs up £400m swoop on car dealer network LookersA UK entity called Global Auto Holdings will unveil an agreed bid for Lookers worth about 120p-a-share as early as Tuesday, Sky News learns.
Read more »
Boojum sold to UK-wide restaurant group that own Zizzi'Boojum is a really strong business, with devoted customers and an exceptionally talented team.'
Read more »