Correlating circulating adipokine levels with COVID-19 severity Coronavirus Disease COVID Diagnostic adipokine IntJObesity
By Suchandrima BhowmikDec 14 2022Reviewed by Benedette Cuffari, M.Sc. A new study in the International Journal of Obesity determines whether plasma adipokine levels were associated with coronavirus disease 2019 -related systemic inflammation, severity, and clinical parameters in mild, severe, and critically ill COVID-19 patients.
In addition to excessive adipose tissue accumulation, obese people also exhibit a dysregulated secretion of inflammatory cytokines and adipokines by adipose tissues. This affects the metabolism of organs and tissue and precipitates a chronic inflammatory state. This chronic inflammatory state worsens COVID-19-associated immunopathology, thus making obese patients susceptible to severe organ injury.
Nasopharyngeal or oropharyngeal swabs were used to confirm severe acute respiratory syndrome coronavirus 2 infection. Patients were treated according to the local COVID-19 protocol. Related StoriesThe median hospital stay was 17 days for critical patients and five days for severe patients. The length of ICU stay was longer for critical COVID-19 patients as compared to critical non-COVID patients.
Visfatin levels were higher in critical COVID-19 patients as compared to severe patients. IL-10, TNF-α, and IL-6 levels were highest among severe and critical COVID-19 patients. Comparable levels were also observed in non-COVID-critical patients. The mortality rate of COVID-19 patients was 43.7%. Critical COVID-19 non-survivors were often older than non-survivors. However, the plasma levels of all adipokines were similar between both the survivors and non-survivors.
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China Reduces COVID Case Reporting as the Virus SurgesAs China relaxes its strict zero-COVID policy, with mass testing no longer obligatory, it has grown more difficult to gauge the true number of cases
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