The study identifies lower potassium isotope ratios in Alzheimer's patients, suggesting δ41K as a viable biomarker for early detection of the disease.
By Pooja Toshniwal PahariaReviewed by Danielle Ellis, B.Sc.Sep 9 2024 Minimally invasive test assesses the relative levels of potassium isotopes in human blood serum and shows the potential to diagnose Alzheimer's disease before symptoms become apparent A recent study in Metallomics investigated stable potassium isotope ratios in serum samples of individuals with Alzheimer's disease .
About the study The present study researchers investigated whether serum δ41K ratios could predict Alzheimer's disease. Researchers separated potassium through cation-exchange chromatography and standard-sample bracketing to measure potassium isotope compositions. Inductively Coupled Plasma Mass Spectrometry determined the mean potassium concentrations. Researchers mechanistically explored mean δ41 K changes. Ab initio calculations predicted potassium isotope fractionation between hydrated potassium and its organic form bound to glutamate and aspartate.
Results Alzheimer's disease patients showed significantly lower average δ41K ratios than controls. Hydrated potassium also showed lower δ41K ratios than organically bound potassium. Serum δ41K values and DFT findings align with literature suggesting the outflow of hydrated potassium ions from the brain to blood . This aligned with a measurable reduction in serological δ41K.
Biomarker Blood Brain Calcium Copper Heparin Hydrogen Peroxide Neurodegenerative Diseases Potassium Protein Stroke Zinc
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