Adverse reactions were short-lived and there were no other safety concerns, researchers found.
And, the research suggests that as the study data was recorded in participants aged 50 and above, there is a possibility such reactions may be more prevalent in younger age groups.
The study reported reactogenicity findings only - how people feel after the vaccine - and not yet the immunogenicity findings, that is how well the mixed dosing worked at inducing an immune response.
"The results from this study suggest mixed dose schedules could result in an increase in work absences the day after immunisation, and this is important to consider when planning immunisation of healthcare workers. "Importantly, there are no safety concerns or signals, and this does not tell us if the immune response will be affected."In the meantime, we have adapted the ongoing study to assess whether early and regular use of paracetamol reduces the frequency of these reactions."
Prof Snape added the number of symptoms did not vary too much depending on which vaccine was given first."It slightly differs according to whether it was chills or fatigue that you're looking at, but actually they were remarkably similar across the board."
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