COVID-19's shifting impact: the changing relationship between infections and severe outcomes PLOSBiology covid COVID19 SARSCoV2 hospitalization hospital severeoutcomes outcomes severe england
By Tarun Sai LomteMay 31 2023Reviewed by Lily Ramsey, LLM A recent study published in the PLOS Biology Journal explored the dynamics of severe acute respiratory syndrome coronavirus 2 infection hospitalization and fatality ratios in England over 23 months.
Consequently, a national lockdown was imposed in January 2021 to curb social contact, with the concurrent implementation of a mass vaccination program. Restrictions were not since re-introduced at a large scale, even when the prevalence was high late in 2021 and during the Omicron waves. Related StoriesData on COVID-19 cases, hospitalizations, deaths, and vaccinations were accessed from an official government website. The time lag from swab positivity to the occurrence of severe outcomes declined throughout the study.During cycles 14-19 , time lags were shorter at seven days to hospitalization and 18 days to death. Contrastingly, time lags were extremely long during cycles 8-13 at 24 days to hospitalization and 40 days to death. The IHR and IFR were estimated to be 2.6% and 0.
IHR and IFR showed a steady decline from September 2021 and were sharply reduced in December 2021, when the proportion of booster vaccine recipients increased. It increased from around 20% in July 2020 to 30% during August-December 2020, with a sharp surge between May and July 2021 and a steep decline between December 2021 and March 2022.
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