Study narrows search for in-use drugs to tackle COVID-19 mutations uniofyork
CoviRx provides users with repurposed drugs that could have anti-viral activity against SARS-CoV-2, based on pharmacological information, assay activity, and drug status in COVID-19 clinical trials. Its user-friendly interface and multi-language support improve data accessibility. Various drug-likeness properties such as molecular weight, logP, hydrogen bond donors , and hydrogen bond acceptors , amongst others, are included for each compound to assist with early drug discovery programs.
5: Tech stack used for development, S5: Tanimoto Coefficient formula, S6:Website general information, Link S7: Code Repository, Link S8: Code Usage, S9: API calls available, S10. Additional information regarding reusability of CoviRx, S11: Supplementary references are included in “CoviRx-supplementary-information” file; “Total list of 214 drugs-table” is shared as a separate file which lists the drugs with the highest activity scores in CoviRx.Conceptualization, H.A.J., A.K., M.M.S., N.L.T., D.
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Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis - BMC MedicineBackground There is growing evidence that patients recovering after a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have a variety of acute sequelae including newly diagnosed diabetes. However, the risk of diabetes in the post-acute phase is unclear. To solve this question, we aimed to determine if there was any association between status post-coronavirus disease (COVID-19) infection and a new diagnosis of diabetes. Methods We performed a systematic review and meta-analysis of cohort studies assessing new-onset diabetes after COVID-19. PubMed, Embase, Web of Science, and Cochrane databases were all searched from inception to June 10, 2022. Three evaluators independently extracted individual study data and assessed the risk of bias. Random-effects models estimated the pooled incidence and relative risk (RR) of diabetes compared to non-COVID-19 after COVID-19. Results Nine studies with nearly 40 million participants were included. Overall, the incidence of diabetes after COVID-19 was 15.53 (7.91–25.64) per 1000 person-years, and the relative risk of diabetes after COVID-19 infection was elevated (RR 1.62 [1.45–1.80]). The relative risk of type 1 diabetes was RR=1.48 (1.26–1.75) and type 2 diabetes was RR=1.70 (1.32–2.19), compared to non-COVID-19 patients. At all ages, there was a statistically significant positive association between infection with COVID-19 and the risk of diabetes: 65 years: RR=1.68 (1.22–2.30). The relative risk of diabetes in different gender groups was about 2 (males: RR=2.08 [1.27–3.40]; females: RR=1.99 [1.47–2.80]). The risk of diabetes increased 1.17-fold (1.02–1.34) after COVID-19 infection compared to patients with general upper respiratory tract infections. Patients with severe COVID-19 were at higher risk (RR=1.67 [1.25–2.23]) of diabetes after COVID-19. The risk (RR=1.95 [1.85–2.06]) of diabetes was highest in the first 3 months after COVID-19. These results remained after taking confounding factors into acco
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