Researchers at QUT's Translational Research Institute have discovered that modified peptides from a Brazilian tarantula and a Japanese horseshoe crab can effectively kill melanoma cells resistant to other therapies. The peptides, originally designed by nature to fight bacterial infections, target the cell membranes of cancer cells, eliminating them without harming healthy cells. This pre-clinical study, published in Pharmacological Research, suggests a potential breakthrough in overcoming drug resistance, a major challenge in melanoma treatment.
Translational Research InstituteDec 19 2024 Antimicrobial peptides derived from a crab and a spider may provide the pathway to overcoming drug resistance in advanced melanoma.
Study last author, QUT Associate Professor Sonia Henriques said that although the study is preliminary with much more research to be done, the results are exciting because drug resistance in melanoma is a huge challenge. The study conducted in both in vitro and in vivo models represents ten years of work and paves the way for further research to make the peptides more potent.
“It is amazing because there are so many peptides in nature and they inspire us as scientists to modify them and make them even more potent and stable,” Dr Benfield said.
Melanoma Drug Resistance Antimicrobial Peptides Cancer Treatment Cell Membrane
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