The effects of curcumin and curcuminoids on a human neuroblastoma cell line (SH-SY5Y) infected with SARS-CoV-2.
By Tarun Sai LomteMay 14 2024Reviewed by Lily Ramsey, LLM In a recent study published in Scientific Reports, researchers investigated the effects of curcumin and curcuminoids on a human neuroblastoma cell line infected with severe acute respiratory syndrome coronavirus 2 .
People with severe COVID-19 manifestations have a higher risk of neurological symptoms. Nevertheless, the underlying neuropathogenesis remains unclear. Curcumin has drawn substantial attention for its potential to treat conditions characterized by inflammatory responses and immune system perturbations.
The study and findings The present study investigated the antiviral, anti-inflammatory, and antioxidant effects of curcumin, curcuminoids, and turmeric extract in SH-SY5Y cells. First, cells were treated with varying concentrations of curcuminoids , turmeric extract, and curcumin and tested for cell viability.
However, TMPRSS11D expression was reduced two-fold. Further, protein levels of TMPRSS2 were decreased by 30% with Me23 treatment, and those of TMPRSS11D declined by 50% with Me08 and 60% with Me23. Next, the team explored the effects of these compounds on ROS production post-SARS-CoV-2 infection.
Covid-19 ACE2 Anti-Inflammatory Antioxidant Cell Cell Line Coronavirus Curcumin Cytotoxicity Immune System Mortality Neuroblastoma Public Health Respiratory SARS SARS-Cov-2 Severe Acute Respiratory Severe Acute Respiratory Syndrome Syndrome Turmeric
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