Xueqing Hu , Ujjwol Khatri , Tao Shen , and Jie Wu, at University of Oklahoma Health Sciences Center, USA, provides a comprehensive review of the role of the RET (REarranged during Transfection) receptor tyrosine kinase in cancer development and the advancements in RET-targeted cancer therapies.
Frontiers JournalsJul 19 2024 Xueqing Hu , Ujjwol Khatri , Tao Shen , and Jie Wu, at University of Oklahoma Health Sciences Center, USA, provides a comprehensive review of the role of the RET receptor tyrosine kinase in cancer development and the advancements in RET-targeted cancer therapies. RET, a transmembrane receptor tyrosine kinase, plays a crucial role in various cellular processes, including embryogenesis and cell development .
Despite these advancements, challenges remain. Many patients exhibit incomplete responses to pralsetinib or selpercatinib, and drug-tolerant residual tumors can evolve resistance, leading to disease progression. The review summarizes the current knowledge and gaps in oncogenic RET alterations and RET-targeted cancer therapy, emphasizing the need to address resistance mechanisms and the future direction toward a cure.
The article also highlights the various methods used to detect RET alterations, such as immunohistochemistry , fluorescent in situ hybridization , DNA-polymerase chain reaction , reverse transcription-PCR , and next-gen sequencing of DNA and RNA. The advantages and disadvantages of these technologies are compared, with a focus on their usage in clinical research and practice.
The review presents data from clinical trials of selpercatinib and pralsetinib, showing their efficacy in terms of objective response rate and duration of response in various RET-altered cancers. The most common adverse events associated with these drugs are also detailed.
Cancer Therapy Cell Cell Development DNA Drugs Embryogenesis Kinase Lung Cancer Non-Small Cell Lung Cancer Receptor Small Cell Lung Cancer Thyroid Thyroid Cancer Transfection Tyrosine
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