Researchers apply artificial intelligence for early risk forecasting of Alzheimer'sdisease hkust NaturePortfolio
Division of Life Science, State Key Laboratory of Molecular Neuroscience, Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen–Hong Kong Institute of Brain Science, Shenzhen, Guangdong, 518057, China Chinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen–Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, Guangdong, 518055, ChinaDepartment of Computer Science and Engineering, The Hong Kong University of Science and Technology,...
John Q. Trojanowski, Leslie M. Shaw, Virginia Lee, Magdalena Korecka, Michal Figurski, Steven E. Arnold, Jason H. Karlawish & David WolkArthur W. Toga, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro & Bryan M. SpannLaurel Beckett, Zaven Khachaturian, Danielle Harvey, Norbert Schuff, Evan Fletcher, Owen Carmichael, John Olichney & Charles DeCarliRobert C. Green, Reisa A. Sperling, Keith A.
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Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors - Nature CommunicationsIt has been reported that inhibition of the epigenetic regulator DNA methyltransferase 1 (DNMT1) is associated with improved response to immune checkpoint blockade (ICB). Here the authors show that conditional deletion of Dnmt1 in endothelial cells is sufficient to promote T cell infiltration, reduce tumor growth and enhance ICB response in preclinical models.
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A rapid theta network mechanism for flexible information encoding - Nature CommunicationsFiltering or gating relevant information into working memory has been attributed to the striatum. Here, the authors reveal neocortical filtering mechanisms, namely, rapid changes in oscillatory theta networks, that predict fast and flexible human behavior.
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Wide-spread brain activation and reduced CSF flow during avian REM sleep - Nature CommunicationsNon-rapid eye movement (NREM) sleep is associated with increased cerebrospinal fluid (CSF) flow in mammals, but this link has not been studied in birds. Here, the authors show that in pigeons, REM sleep is associated with activation of visual brain regions and a drop in CSF flow, suggesting that REM sleep functions occur at the expense of waste clearance during NREM sleep.
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Vesicular glutamate transporters are H+-anion exchangers that operate at variable stoichiometry - Nature CommunicationsIn glutamatergic neurons, synaptic vesicles contain glutamate, but not aspartate. Here, the authors show that vesicular glutamate transporters are H+/anion exchangers that attain high selectivity for glutamate via variable transport coupling.
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I'm an ex-paramedic - here's the cheap cough medicine swap parents need to knowIT’S always distressing when you hear your little one suffer with a nasty cough. To make matters worse, over-the-counter treatments don’t always work, could have side-effects or be toxi…
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New study finds that women and underrepresented groups experience sexual harassment in academic medicineA new study led by Winship Cancer Institute of Emory University researcher Reshma Jagsi, MD, DPhil, has found that women, racial and ethnic minorities and individuals identifying as lesbian, gay, bisexual, transgender and queer are disproportionately affected by workplace mistreatment in academic medicine, and this mistreatment negatively impacts their mental health.
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