Cancer's origin story features predictable plot line, researchers find sumedicine nature
deficiency elicits a temporally defined order of genomic aberrations raises the possibility that these features may similarly predict progression to CIN GC. Future evaluation of this hypothesis will require annotated intestinal metaplasia tissue collection with long-term follow-up.
By joint measurement of lineage, CNAs and transcriptional states in individual cells, we investigated the molecular basis of clonal expansions and fitness. This showed stringent selection and reproducible subclonal dynamics across replicate cultures in which the same, initially rare, subclone fixed in the population.
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