Blood vessels in the lungs aren't like the others in the body. This difference becomes clear in pulmonary hypertension, in which only the lungs' blood vessels stiffen progressively, leading to chronic lung disease, heart failure and death.
Blood vessels in the lungs aren't like the others in the body. This difference becomes clear in pulmonary hypertension, in which only the lungs' blood vessels stiffen progressively, leading to chronic lung disease , heart failure and death. The underlying reasons for this organ-specific vessel stiffening remained a mystery until researchers made a surprising discovery about these blood vessel cells in patients with pulmonary hypertension -- they're hungry.
Amino acids are the building blocks of proteins, which help build cellular structures, carry out biological functions, and regulate tissue and organ function. As hypertensive pulmonary blood vessels metabolize glutamine and serine, they create two new amino acids, called proline and glycine.
For patients with pulmonary hypertension, avoiding foods rich in serine and glutamine, or eating foods with these amino acids depleted, might bolster the effectiveness of current medications."It opens up a new way that we could treat this disease, because now -- instead of just relying on medications and transplantation -- there are possibly effective lifestyle interventions," says Chan.
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