A living cell is a bustling metropolis, with countless molecules and proteins navigating crowded spaces in every direction.
Center for Genomic RegulationOct 29 2024 Cell division is a grand event which completely transforms the landscape. The cell starts behaving like the host of an international competition, reconfiguring entire streets, relocating buildings and rerouting its transportation systems.
Yet, despite its critical importance, the exact mechanisms governing how cells reorganize their insides during cell division have remained a mystery. How does a cell know when and how to rearrange its internal scaffolding? What are the molecular signals governing these changes? Who are the key players conducting it all?
At the heart of the discovery is the protein PRC1. During cell division, PRC1 plays a key role in organising cell division. It crosslinks microtubules, helping to form a structure in the crucial region where microtubules overlap and chromosomes are separated. We discovered that manipulating the phosphorylation state of PRC1 can induce large-scale transitions between different states of cytoskeleton organization that are needed for cell division. The changes take only a few minutes to complete.
Cancer Cell Division Cytoskeleton Genomic In Vitro Phosphorylation Protein Research
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