A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study.
University of BirminghamOct 14 2024
The team led by Professor Jo Morris from the University of Birmingham's Department of Cancer and Genomic Sciences have identified that USP50 determines which or the many helicases and nucleases are used during ongoing replication, fork restart, and the maintenance of telemores, the DNA-rich protein structures on the ends of chromosomes.
This discovery may be an important step to understanding how some hereditary gene changes lead to early onset ageing and cancer." Attempted workaround The study also found that when USP50 is absent during replication activity, cells attempted to use various nucleases and helicases in a less coordinated fashion leading to replication defects in cells.
DNA Replication Protein Cancer Genetics Genomic
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