Virtually every cell in the human body has an internal clock. These clocks take their cues from a central clock in the brain. In a normal, biological process called synchrony, the central clock coordinates daily rhythms around the body, so that every cell and tissue recognizes the same external time of day.
Washington University in St. LouisDec 13 2024
Blocking the daily surge in glucocorticoid signaling desynchronizes circadian rhythms in glioblastoma from the host and dramatically slows disease progression in tumor-bearing mice." "Our previous research helped us to see a pattern," said Maria F. Gonzalez-Aponte, PhD, first author of the study. "Whether we were looking at clinical data, or patient-derived cells or mice with model glioblastoma tumors, chemotherapy treatment always worked best around normal waking time.
"The interaction between brain tumors and the circadian system is now a targetable mechanism to optimize treatments," Herzog said. She placed tumor-bearing mice in cages that could be made light or dark using a timer. By shifting when she turned on the lights, Gonzalez-Aponte coaxed the mice into adopting a flipped schedule. She could tell it was working by observing when each day the mice started running in their wheels.
Similarly, the tumors remained synchronized to the host in conditions where the mice woke and slept according to their own circadian cycles in the absence of any environmental timing cues.
Brain Cancer Brain Tumor Cancer Cell Chemotherapy Cortisol Edema Glioblastoma Glucocorticoid Malignant Research Sleep Steroid Surgery Tumor
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