Researchers determine whether cannabis use disorder increases the risk of head and neck cancer.
By Dr. Liji Thomas, MDReviewed by Benedette Cuffari, M.Sc.Aug 12 2024 A recent study published in JAMA Otolaryngology Head & Neck Surgery determines whether cannabis use disorder increases the risk of head and neck cancer .What is HNC? HNC is the sixth leading cause of cancer throughout the world. In 2020, over 870,000 HNC cases were reported globally, 440,000 of which resulted in death. In the United States, HNC is responsible for about 3% of all cancers and over 1.
Despite its potential therapeutic effects for these conditions, cannabis use remains controversial, as it may increase the risk of developing psychotic disorders and cognitive defects. Furthermore, the smoke content of cannabis contains carcinogens similar to those found in cannabis, such as polycyclic aromatic hydrocarbons and nitrosamines. Tetrahydrocannabinol , which is the primary psychoactive component in cannabis, also promotes the conversion of PAHs to carcinogens.
What did the study show? The CUD group comprised 116,076 people, about 45% of whom were women and 60% were White with a mean age of 46.4 years. About 19% of patients with CUD reported tobacco use, whereas 22.6% reported alcohol use. This increased risk was consistently observed in older and younger age patients for cancers reported one or more years after the first outpatient visit. Although the risk of any HNC remained significant five or more years after the first outpatient visit, it was no longer significant for HNC subsites. This loss of strength for associations with HNC at five or more years from the reporting of CUD may be due to low sample sizes, other confounding factors, and variations in cannabis use.
Cannabis Head And Neck Cancer Neck Alcohol Larynx Otolaryngology Surgery Tobacco
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