Dopamine and serotonin balance reward learning in opposing ways

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Dopamine and serotonin balance reward learning in opposing ways
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If you've heard of two of the brain's chemical neurotransmitters, it's probably dopamine and serotonin. Never mind that glutamate and GABA do most of the work -; it's the thrill of dopamine as the 'pleasure chemical' and serotonin as tender mood-stabilizer that attract all the headlines.

Stanford UniversityNov 25 2024 If you've heard of two of the brain's chemical neurotransmitters, it's probably dopamine and serotonin. Never mind that glutamate and GABA do most of the work -; it's the thrill of dopamine as the "pleasure chemical" and serotonin as tender mood-stabilizer that attract all the headlines.

Robert Malenka, study senior author, the Pritzker Professor of Psychiatry and Behavioral Sciences at Stanford The experiment: dual control of dopamine and serotonin during associative learning Led by graduate student Daniel Cardozo Pinto, the research team created specially engineered mice that allowed them to observe and control both dopamine and serotonin systems in the same animal.

The researchers then used optogenetic manipulation to selectively blunt the normal signaling of each system -; either alone or in combination -; during reward learning.

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