Science, Space and Technology News 2024
Duke Health researchers have found that aging-related liver damage might be reversible by targeting a specific type of cell death with a drug, offering hope for millions suffering from liver diseases exacerbated by metabolic stresses.The liver, despite being one of the body’s most robust organs, remains susceptible to damage from stress and aging, which can lead to disease, significant scarring, and even organ failure. Researchers atmay have discovered a method to rejuvenate the liver.
“We found that aging promotes a type of programmed cell death in hepatocytes called ferroptosis, which is dependent on iron,” Diehl said. “Metabolic stressors amplify this death program, increasing liver damage.” Upon analysis after treatment, the livers of the animals given Ferrostatin-1 looked biologically like young, healthy livers — even in the old animals that were kept on the disease-inducing diet.
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