Duping antibodies with a decoy, researchers aim to prevent rejection of transplanted cells ucsf NatureBiotech
."This issue is likely to be a severe obstacle in any type of allogeneic cell transplantation."
The researchers genetically engineered three types of cells—insulin-producing pancreatic islet cells, thyroid cells, and CAR-T cells—so that each type made and displayed large numbers of a protein called CD64 on their surfaces. "We saw that we can snatch up high levels of these antibodies, which resulted in very robust protection for theThere's more work to do before the approach can be tested on cells that are designed to be therapeutics or transplanted cells, he said. While such cells are biologically sophisticated, they are also expensive and hard to manufacture.
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