Immortals of Aveum, the first-person magic shooter from Ascendant Studios and publisher EA, has been delayed by one month for further polish, optimisation and to “deliver a strong launch”
the delay would give the studio additional time for polishing and optimisation in order to fulfil its vision for the game.
“Along the way, we worked through a pandemic, built a new team, developed on Unreal Engine 5.1 and pushed the boundaries of what we thought was possible. Now, the finish line is in sight.
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Immortals of Aveum delayed to AugustAscendant Studios and EA have delayed Immortals of Aveum, meaning the first-person shooter will no longer launch in July as originally planned.
Read more »
New Council partnership with WSP set to deliver range of benefits for ShropshireShropshire Council says a new partnership with WSP will help improve the county’s roads, attract inward investment to Shropshire, keep money in the county and help meet the council’s net zero and climate change targets.
Read more »
Jane Seymour looks ageless in plunging dress to deliver special messageThe 72-year-old radiated positivity in her uplifting post
Read more »
Hijacked S3 buckets used in attacks on npm packagesCybercrooks use abandoned AWS storage tool to deliver malware
Read more »
Plans for free tennis and coaching following refurbishment of courtsA planned six-figure investment in run-down tennis courts could deliver the next Andy Murray in Renfrewshire, an elected member has said.
Read more »
Frontiers | CD34+ HSPCs-derived exosomes contain dynamic cargo and promote their migration through functional binding with the homing receptor E-selectinExosomes are the tiny vesicles released by cells that carry communications to local and distant locations. Emerging research has revealed the role played by integrins found on the surface of exosomes in delivering information once they reach their destination. But until now, little has been known on the initial upstream steps of the migration process. Using biochemical and imaging approaches, we show here that exosomes isolated from both leukemic and healthy hematopoietic stem/progenitor cells can navigate their way from the cell of origin due to the presence of sialyl Lewis X modifications surface glycoproteins. This, in turn, allows binding to E-selectin at distant sites so the exosomes can deliver their messages. We show that when leukemic exosomes were injected into NSG mice, they traveled to the spleen and spine, sites typical of leukemic cell engraftment. This process, however, was inhibited in mice pre-treated with blocking E-selectin antibodies. Significantly, our proteomic analysis found that among the proteins contained within exosomes are signaling proteins, suggesting that exosomes are trying to deliver active cues to recipient cells that potentially alter their physiology. Intriguingly, the work outlined here also suggests that protein cargo can dynamically change upon exosome binding to receptors such as E-selectin, which thereby could alter the impact it has to regulate the physiology of the recipient cells. Furthermore, as an example of how miRNAs contained in exosomes can influence RNA expression in recipient cells, our analysis showed that miRNAs found in KG1a-derived exosomes target tumor suppressing proteins such as PTEN.
Read more »