Multiple myeloma is one of the most common forms of cancer of the immune cells in the bone marrow. It is considered incurable.
Charité - Universitätsmedizin BerlinJul 1 2024 Even when patients respond to treatment at first, the cancer comes back. To be able to intervene faster and on a more targeted basis, researchers at Charité – Universitätsmedizin Berlin, the Berlin Institute of Health at Charité , and the Max Delbrück Center teamed up with other partners for a comprehensive study of this disease at the molecular level.
Over the course of the disease, most patients develop tumors at various locations in the bone marrow, hence the "multiple" in the disease's name. Immunodeficiency, kidney failure, bone loss, and bone fractures are just some of the consequences of this uncontrolled cell growth. Despite advances in treatment and the introduction of new gene and cell therapies, there is no cure for multiple myeloma at present.
But what causes so much divergence in the course of multiple myeloma? In cooperation with protein analysis experts from the Max Delbrück Center and BIH, the researchers conducted a detailed study of genetic and molecular changes occurring in the tumor cells in a group of more than one hundred patients. The study included data from patients in the German Multiple Myeloma Study Group , which is coordinated by the University Hospital of Würzburg.
"Genetic data alone is insufficient to explain the mechanisms involved in this disease," Mertins says. "We wanted to know the consequences of genetic changes at the protein level and compare this molecular biology data against the actual course of the disease in patients." The team was supported in collecting and analyzing the large volumes of data by experts at Charité, BIH, and the German Cancer Consortium .
Myeloma Antibodies Bone Bone Marrow Cancer Cell Chromatography Genetic Hematology Immunology Ion Liquid Chromatography Mass Spectrometry Medicine Oncology Protein Proteomics Research Spectrometer Spectrometry Technology Tumor
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